假细锥香茶菜新二萜成分——假细锥甲素的结构

从假细锥香茶菜(Rabdosia coetsoides C.Y.Wu)叶分离得到新二萜成分,根据紫外光谱、红外光谱、质谱、核磁共振氢谱及碳谱等分析,推定了化学结构,并经X-射线衍射确证,命名为假细锥甲素。     

砂仁真菌病害的鉴定

砂仁(Amomum villosum Lour.)为著名南药,生产上有多种病害,以叶斑病为害严重而影响产量。作者1985年、1986年,在砂仁的重要产地阳春、封开等县进行了调查,认为目前主要有五种真菌病害:其中炭疽病两种:幼苗炭疽病为姜刺盘孢(Colletotrichum zingiberis(Sundar.)Butler et Bisby),成株炭疽病为盘长孢状刺盘抱(Colletotrichumgloeosporioides Penz.);果腐病两种,多数为茄丝核菌(Rhizoctonia solani Kuhn.),少数为镰刀菌(Fusaium sp.)引起;最影响生产的是叶斑病,其病原菌砂仁节梨孢(Gona-topyricularia amomi Z.D.Jiang et P.K.Chi)是个新属新种。本文较详细地描述了五大病害的症状及其病原菌的形态,并报道了各病菌的致病性测定结果。     

升麻一新变种

本文报道四川产升麻一新变种紫花升麻Cimicifuga foetida L.var.purpurea C.Huang,var.nov.,对新变种作了特征集要描述,并应用光学显微镜和扫描电镜,对升麻Cimicifuga foetida L.和新变种的花粉形态特征作了比较观察。     

Ubiquitin in motor neuron disease: study at the light and electron microscope.

Several neurodegenerative diseases, including motor neuron disease (MND), are characterized by formation of abnormal cytoskeleton-derived inclusions which contain ubiquitin (Ubq). We have studied the distribution of Ubq in 26 cases of MND with light and electron microscopic immunocytochemistry. Ubiquitin-positive inclusions were found in neurons of anterior horns in most cases of amyotrophic lateral sclerosis (ALS) but were not present in other forms of MND. Ubiquitin immunoreactivity was observed in 10-15 nm intraneuronal filaments, which were not stained by antibodies to neurofilaments, and on dense bodies of dystrophic neurites throughout the neuropil of anterior horns and pyramidal tracts. Data analysis showed a trend toward lower percentage of Ubq-positive neurons in cases with longer duration of illness or lower number of neurons. A high percentage of Ubq-positive inclusions occurred in cases with an aggressive clinical course, suggesting that ubiquitination takes place at early stages of the disease.     

Do insertion-related problems affect subsequent IUD performance?

This investigation compares the IUD performance of 372 women who had an insertion-related problem (most with moderate or severe pain) and 372 matched women who had no such problem; all women had interval insertion. A woman in the Problem Cohort and her matched counterpart in the Comparison Cohort were inserted with the same IUD type by the same insertor on the same day or on close dates. The six IUD types used by these women were Lippes Loop D, Copper-7, Copper T-200, Copper T-380 Ag, Multiload Copper 250 and Multiload Copper 375. Cumulative gross life-table rates of the pertinent events (accidental pregnancy, expulsion and medical removal for bleeding and pain), adjusted for age and parity, were calculated. Between the Problem Cohort and the Comparison Cohort, no differences were detected in the event rates that were of either statistical or practical significance. Results from this preliminary study suggest that the insertion-related problems usually encountered during interval insertion such as insertion pain, syncope and/or mild cervical laceration are not associated with an increased risk of IUD discontinuation due to pertinent events.     

小鼠脑缺血后的能量代谢改变和药物的作用

应用部分结扎小鼠颈总动脉(包括迷走神经)及小鼠断头法引起脑缺血后,脑组织的ATP和磷酸肌酸明显降低,乳酸明显升高。部分结扎颈动脉出现四肢无力、转圈及昏睡等症状,其严重程度与脑能量代谢改变相平行。皮下注射尼莫地平、硝苯吡啶、尼卡地平和三七皂甙对脑缺血有一定保护作用。苯巴比妥钠能改善正常和脑缺血小鼠的脑能量代谢,人参皂甙Rb₁可降低正常小鼠脑乳酸含量。     

双氯芬酸制剂研究进展

双氯芬酸为邻羟基苯乙酸类非甾体抗炎药,具有较强的抗风湿、抗炎、镇痛和退热作用,常用于治疗急性或慢性类风湿关节炎、骨关节炎及创伤和术后炎性疼痛等.常用的给药途径有口服、经皮给药、眼科外用和直肠给药等,已上市的剂型包括片剂、胶囊剂、凝胶剂及滴眼液等,根据疼痛疾病的发病变化规律,研究可以长时间平稳或者可以快速起效的双氯芬酸缓释和控释制剂成为了近年来的主要趋势.     

腹膜透析与中药灌肠结合治疗慢性肾衰

报道4例慢性肾功能衰竭病人在进行持续性腹膜透析治疗中出现腹腔感染及透析管堵塞时,改为中药灌肠替代,同样起到缓解症状作用,使生存期延长3～7个月。提出根据不同情况采用中药灌肠与间歇性腹膜透析交替使用,替代不卧床持续性腹膜透析。认为此法在一定程度上可以解决上述问题。